![]() First, we have generated transgenic animals that allow us to visualize and probe neurodevelopment in vivo and with single cell resolution. ![]() Our lab is undertaking three experimental approaches to examine the development of neural circuitry. elegans greatly facilitate neurodevelopmental studies. elegans synapses share many features with mammalian synapses at both morphological and molecular levels, suggesting conserved mechanisms of synapse assembly and function. Second, despite the relative simplicity of its nervous system, C. It is the only metazoan for which the entire nervous system has been reconstructed by serial electron microscopy. elegans has a simple and well-defined nervous system with 302 neurons that form about 5000 chemical synapses. elegans to examine this question in vivo. We are interested in understanding the development of neuronal circuitry, and we use C. How the brain develops is not well understood. ![]() There are more neurons in a single human brain than stars in the milky way! During development, neurons navigate this complex cellular environment and assemble into functional circuits. The human brain consists of 100 billion neurons and over 100 trillion synaptic connections.
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